Idarubicin and IR780 co-loaded PEG-b-PTMC nanoparticle for non-Hodgkin’s lymphoma therapy by photothermal/photodynamic strategy

•An effective nanoparticle system for carrying IR780 and Idarubicin was designed to combine PTT/PDT and chemotherapy to treat NHL.•Upon near-infrared laser irradiation at 808 nm, PEG-b-PTMC nanoparticle showed strong PTT/PDT efficacy with high-efficiency endocytosis and increasing reactive oxygen species (ROS) generation.•IR780 + IDA NPs has been successfully delivered and exhibited significant synergistic effects on inhibiting cell proliferation in Raji and U937 cells.•IR780 + IDA NPs shows a significant therapeutic effect on lymphoma and has excellent biocompatibility and safety in vivo.