Impact of early pericardial fluid chymase activation after cardiac surgery.

Brittany Butts,Lee A Goeddel,Jingyi Zheng,Betty Pat,Pamela Powell,James Mobley,Sarfaraz Ahmad,Chad Steele,David McGiffin,James E Davies,James F George,Spencer J Melby,Carlos M Ferrario,Louis J Dell'Italia

Frontiers in cardiovascular medicine（2023）

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摘要

Early postoperative PCF chymase activation underscores its potential role in cardiac damage soon after on- or off-pump cardiac surgery. In addition, chymase in extracellular vesicles provides a protected delivery mechanism from neutralization by circulating serine protease inhibitors.

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关键词

chymase,extracellular vesicles,exosomes,cardiovascular surgery,inflammation,length of stay

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