Controlled Synthesis of Copolymers of N-Vinylsuccinamic Acid and Vinyl Alcohol for Immobilization of Low-Molecular-Weight Biologically Active Substances

Controlled radical polymerization of N-vinylsuccinimide with vinyl acetate via the reversible addition‒fragmentation chain-transfer mechanism in the presence of dibenzyl trithiocarbonate has been carried out. The polymerization kinetics and molecular-mass characteristics of the resulting polymers have been studied using NMR spectroscopy and gel permeation chromatography. The monomer reactivity ratios have been evaluated, and the gradient microstructure of the copolymers is described. Water-soluble polymer matrices based on N-vinylsuccinamic acid–vinyl alcohol copolymers have been obtained for the immobilization of low-molecular-weight compounds exhibiting bioactive properties. The absence of bactericidal activity of the synthesized matrices has been shown using bacterial culture models. Oil-soluble rimantadine and trimecaine were converted into a water-soluble form by interaction with the obtained copolymer.