Rescue of EndMT-associated endothelial dysfunction by modulating the YAP pathway

Nature Cardiovascular Research（2023）

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摘要

Statins exert cardiovascular protective effects that are independent of cholesterol lowering. Using endothelial cells derived from induced pluripotent stem cells, Liu et al. show that statins can improve endothelial dysfunction by inhibiting endothelial–mesenchymal transition via epigenetic regulation of the GGTase–RhoA–YAP1–SOX9 signaling pathway.

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关键词

endothelial dysfunction,yap pathway,endmt-associated

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