Identification and synthesis of new process impurities of amlodipine, a calcium channel blocker
JOURNAL OF HETEROCYCLIC CHEMISTRY(2023)
Abstract
Amlodipine belongs to the class of calcium channel blocker that is used to reduce high blood pressure (hypertension). Two related substances of amlodipine namely 3-(2-[1.3-dioxo-1,3-dihydro-2H-isoindol-2-yl]ethyl)-5-methyl-(4RS)-4(2-chlorophenyl)-2-([2-(1,3-dioxo-1,3-dihydro-2H-isoin-dol-2-yl)ethoxy]methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (11) and 3-([2-aminoethyl]-5-aminoethoxy)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate (12) were identified. The present work describes the origin, synthesis, and characterization of these related substances.
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Key words
amlodipine,calcium,new process impurities
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