A one-pot access to 2-(N-substituted Amino)-Quinones or 3-indolyl- Quinones from naphthol/hydroquinone

A sequential one-pot approach towards 2-(N -substituted amino)-1,4-quinones or 3-indolyl-quinones from naphthol/hydroquinone with amines or indoles, such as various (hetero)aromatic amine and aliphatic amine, has been developed. The reaction proceeds through oxidation of naphthol/hydroquinone with the CuBr2 or (NH4)2S2O8 oxidant. This reaction provides efficient access to the biologically impor-tant and synthetically useful 2-amino-quinones and 3-indolyl-quinones with good yields under mild conditions. The present protocol is simple, practical and shows good functional group tolerance. (c) 2023 Elsevier Ltd. All rights reserved.