Analysis of bisphenol-propane in dialyzer and its effect on human body
MATERIALS EXPRESS(2023)
Abstract
The effect of trace solvent bisphenol A (BPA) in polyether sulfone hollow fiber membrane EnttexTM-16LF (E60) (produced by 3 M) low-throughput dialyzer was tested in this study. Animal experiments were conducted to evaluate its genotoxicity, carcinogenicity, and teratogenicity upon chronic exposure. The dialyzer was operated at 200 mL/min and 400 mL/min and coupled with LC-20AT liquid chromatography to detect BPA, which showed that the BPA content was less than 5 mu g/kg/d at both flow rates. In animal experiments, the tolerable intake (T.I.) was calculated to be 0.5 mu g/kg/d. With hemodialysis three times per week, the average patient weight was calculated at 70 kg, and the average daily BPA exposure was 0.0306 mu g/kg/d. The risk of residual BPA was within the acceptable limit with polyether sulfone membrane EnttexTM-16LF (E60) hollow fiber dialyzer from 3 M, without inducing risk for disability, teratogenicity, or genotoxicity.
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