Peritumoral and Intratumoral Lymphocytic Infiltration and Stromal Reaction in High-Risk Endometrioid Carcinomas

Objective: This study aims to evaluate the relationship between the local immune response such as peritumoral and intratumoral lymphocytic infiltration and stromal reaction, with prognosis and other clinicopathological parameters in high-risk endometrioid carcinomas. Method: Totally 98 high-risk cases diagnosed as endometrioid carcinoma in our center between 2005 and 2017, were retrieved from the pathology archives and re-evaluated. Results: Totally 98 cases diagnosed as high-risk endometrial carcinoma were evaluated. Intratumoral and peritumoral lymphocytic infiltration was compared to overall survival period and overall survival was significantly higher in tumors showing peritumoral and intratumoral lymphocytic infiltration (p=0.000 More