Fathers, Mothers, Saints, Martyrs: Religion as a Lineage of Belief

This study aimed to evaluate the hepatic antioxidant activity of a high-fat diet supplemented with chia oil in mice. Forty animals were divided into Control (C, n = 10), Control + 1.5 % chia oil (CC, n = 10), High fat (HF, n = 10), and High fat + 1.5 % chia oil (HFC, n = 10) groups. Chia oil reduced serum triacylglycerol in the HF group (p < 0.05). Chia oil promotes lower hepatic concentrations of F2-isoprostane (8-epi PGF2 alpha) and thiobarbituric acid (TBARs) than HF. Chia oil increased liver protein expression and activity of superoxide dismutase 1 and 2 (SOD1 and SOD2), catalase (CAT), and glutathione peroxidase (GPx). It also upregulated the expression of PPAR gamma and NRF2, a master transcription factor involved in the antioxidant response in the liver, compared to their counterparts. The results reveal that chia oil improves the metabolic and antioxidant systems in the liver of highfat diet-fed mice.