Three new sesquilignans from the stems of Eleutherococcus senticosus and their bioactivities

Three new sesquilignans, Eleutherocosus A (1), Eleutherocosus B (2) and Eleutherocosus C (3) together with seven known lignans (4 -10) were isolated from the EtOAc-soluble extract of Eleutherococcus senticosus. Their structures were elucidated by the basis of spectroscopic and physicochemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 1 -3 exhibited the most potent inhibitory activity on DGAT1 with IC50 values of 71.4 +/- 1.3, 79.1 +/- 1.1 and 65.2 +/- 1.2 mu M, respectively.