A novel RIPK1 inhibitor attenuates GVHD

BLOOD(2023)

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摘要
In this issue of Blood, Yu et al identify the role of enterocyte RIPK1/RIPK3 in the generation of graft-versus-host disease (GVHD) and generate a potent RIPK1 inhibitor, Zharp1-211, which inhibits GVHD without impacting graft -versus-leukemia (GVL) in a murine model.(1)
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novel ripk1 inhibitor
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