Adsorption and Release of Diphenhydraminium Ibuprofenate from SBA-15 and MCM-41 Explained by Intermolecular Interactions

The loading of Active Pharmaceutical Ingredient Ionic Liquid (API-IL)—diphenhydraminium ibuprofenate ([DIP][IBU])—on mesoporous silica (SBA-15 and MCM-41) was evaluated from intermolecular interactions point-of-view, which advance from a discussion focused on surface area and pore volume of silica matrices. The rate of [DIP][IBU] release was also evaluated in two different mediums (PBS pH 7.2 with 1