Synthesis and Biological Activity of 4-(3,4-Dibromothiophenecarbonyl)-2,6,8,10,12-Pentaacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane: A New Non-Narcotic Analgesic of the Hexaazaisowurtzitane Class
PHARMACEUTICAL CHEMISTRY JOURNAL(2023)
Abstract
A method for production of a promising non-narcotic analgesic of the hexaazaisowurtzitane class is developed. Data on the physicochemical characteristics and conditions for obtaining the target substance are presented. The effectiveness of the resulting agent is shown in several animal models. A pronounced analgesic effect of the newly synthesized compound 4-(3,4-dibromothiophenecarbonyl)-2,6,8,10,12-pentaacetyl-2,4,6,8,10,12-hexaazaisowurtzitane comparable or even superior to that of tramadol was revealed.
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Key words
synthesis,non-narcotic
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