Synthesis, transformation and preliminary bioassay of 3-(thiazol-2-yl(p-tolyl)amino)propanoic acid derivatives

1,3-Thiazole is one of the most attractive cores in heterocycles chemistry and drug discovery. Its widespread use in diverse medicinal substances makes thiazole a versatile scaffold, which leads to the novel generation of efficient pharmaceuticals. This study was intended to synthesize a se-ries of N,N-disubstituted aminothiazole derivatives having various frag-ments at the 4th and 5th positions of the thiazole ring. The formation of such derivatives was carried out via the Hantsch reaction, conden-sation reactions with various aldehydes, bromination and formation of the chalcone-type derivatives. Another goal of this study was to inves-tigate the antibacterial properties of the obtained compounds against some gram-positive Bacillus species such as B. coagulans, B. subtilis and B. megaterium and gram-negative Escherichia coli. As it is shown by our studies in recent years, the synthesized thiazoles can serve for future development of potent thiazole derivatives for various medicinal targets.