Revealing genetic links of Type 2 diabetes that lead to the development of Alzheimer’s disease
HELIYON(2023)
Abstract
•The study extracted the most significant genes in common of T2D and AD such as CDKN1A, COL22A1, EIF4A, GFAP, SLC1A1, and VIM.•The hub genes of AD-related genes were validated using network-based methods.•Notional genetics mechanisms of T2D involvement in AD etiology are presented.
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Key words
Alzheimer ?s disease,Type 2 diabetes mellitus,Neovascular unit,Differential expression,Ageing brain
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