Characterizing Rosai-Dorfman disease with [F-18]FDG PET/CT: a retrospective analysis of a single-center study

ObjectivesRosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytic proliferative disorder. We performed a retrospective study to characterize the clinical and [F-18]FDG PET/CT features of RDD.MethodsWe retrospectively recruited 38 RDD patients with [F-18]FDG PET/CT scan in our center. [F-18]FDG PET/CT features were assessed, and clinical and follow-up data were recorded.ResultsIn the recruited patients, 20/38 (52.6%) patients had single-system disease, while others (18/38, 47.4%) had disease affecting multiple system. RDD most commonly involved the upper respiratory tract (47.4%), followed by cutaneous/subcutaneous lesion (39.5%), lymph node (36.8%), bone (31.6%), central nervous system (28.9%), and cardiovascular system (13.2%) in the recruited patients. In PET/CT, the RDD lesions were FDG-avid, and the SUVmax of the hottest lesion in an individual patient was positively correlated with C-reactive protein levels (r = 0.418, p = 0.014), and negatively correlated with hemoglobin levels (r = -0.359, p = 0.036). The overall response rate of the first-line treatment was 80.8% in newly diagnosed RDD patients, and for patients with relapsed/progressive RDD, the overall response rate was 72.7%.Conclusion[F-18]FDG PET/CT could be a useful tool for evaluating RDD.