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EpiCRISPR targeted methylation of Arx gene initiates transient switch of mouse pancreatic alpha to insulin-producing cells.

Marija Đorđević,Peter Stepper,Clarissa Feuerstein-Akgoz,Clarissa Gerhauser,Verica Paunović,Anja Tolić,Jovana Rajić,Svetlana Dinić,Aleksandra Uskoković,Nevena Grdović,Mirjana Mihailović,Renata Z Jurkowska,Tomasz P Jurkowski,Jelena Arambašić Jovanović,Melita Vidaković

Frontiers in endocrinology（2023）

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Abstract
In conclusion, we successfully triggered a direct, transient switch of pancreatic alpha to insulin-producing cells opening a future research on promising therapeutic avenue for diabetes management.
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Key words
Arx gene,CRISPR/dCas9,diabetes,epigenetic editing,pancreatic alpha cells,targeted DNA methylation
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