Synthesis of Spiro-Oxindole-Pyrrolidines via [3 + 2]-Cycloaddition of Non-stabilized Azomethine Ylide
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY(2023)
Abstract
A representative series of 12 spiro-pyrrolidine-fused oxindoles have been synthesized via [3+2]-cycloaddition of nonstabilized azomethine ylide to the conjugated double bond of 3-aryl-2-[1,4-dioxo-3,4-dihydrophthalazine-2(1 H )-carbonyl]prop-2-enenitriles. The reactions are chemo-, stereo-, and regioselective.
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Key words
[3+2]-cycloaddition,spiro-pyrrolidine,multicomponent synthesis,azomethine ylides
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