Synthesis of New Cyclohexenone Derivatives Using Potassium Phthalimide as a Green Organocatalyst. One-Pot Microwave-Assisted Synthesis and Antimicrobial Evaluation
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY(2023)
摘要
A direct one-pot three-component reaction of 4-acetyl-N-benzylbenzamide, ethyl acetoacetate or methyl acetoacetate, and aromatic aldehydes under microwave irradiation afforded a series of new cyclo-hexenone derivatives. The proposed procedure has the advantages of one-pot reaction, high efficiency, short reaction time, and simple workup. The antimicrobial activity of the obtained cyclohexenone derivatives was tested against a variety of bacteria (E. coli, S. aureus, S. pyogenes, P. aeruginosa) and fungi (C. albicans, A. niger, A. clavatus).
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关键词
cyclohexenone derivatives,potassium phthalimide (PPI),one-pot synthesis,microwave irradiation,antimicrobial activity
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