Retrospective Evaluation of P-wave Dispersion on ECG in Terms of Atrial Fibrillation Dispersion in Patients Using Alpha-blockers for Lower Urinary Tract Symptoms

Objective: The incidence of benign prostatic hyperplasia (BPH) directly increases with age, and side effects related to drugs in the alpha-blocker group used in these patients are more important. In this study, we evaluated the safety of tamsulosin in cardiac arrhythmias, which are common in this age group.Methods: Between May and June 2017, 835 patients with BPH were evaluated retrospectively. Patients with cardiovascular and endocrine system diseases were excluded from the study. Tam In 55 patients who met the study criteria, tamsulosin was started as BPH treatment. Moreover, a control group was formed with patients who had not on tamsulosin treatment yet. Electrocardiographies (ECGs) of 37 patients who completed 3 weeks of tamsulosin use were obtained. Control and reference P-wave distribution (PWD) were calculated for each patient. The difference between the largest and narrowest p-waves on the ECG was calculated to determine the PWD. PWD values before and after treatment were compared.Results: The mean age was 53.6 +/- 8 years. PWD values in reference and control ECG were calculated and compared. While the mean PWD was 55 ms (30-75) before tamsulosin use, it was 60 ms (45-70) 3 weeks after tamsulosin use.Conclusion: PWD change in ECG was found to be significant in patients with BPH patients treated with tamsulosin. According to the results, I an increase in PWD is a finding that indicates an increased risk of supraventricular tachycardia. Therefore, the clinician should be more careful when using tamsulosin in these patients.