(S)-N-1,N-3-Dibenzyl-1-cyclohexyl-N-1,N-3-bis((R)-1-phenylethyl)propane- 1,3-diamine

MOLBANK(2023)

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Abstract
(S)-N-1,N-3-dibenzyl-1-cyclohexyl-N-1,N-3-bis((R)-1-phenylethyl)propane-1,3-diamine was prepared in good yield by the reduction of the corresponding amide, which was obtained by the addition of a chiral lithium amide to an alpha,beta-unsaturated ester. The target compound was fully characterized by NMR (H-1 and C-13), high-resolution mass spectrometry and polarimetry.
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Key words
1,3-diamine,chiral auxiliar,chiral lithium amide,organocatalysis,aza-Michael addition
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