Fluorescent indicator displacement assay for the discovery of UGGAA repeat-targeted small molecules

Tomonori Shibata,Yasumasa Matsumoto,Akiko Iihara,Kazunori Yamada,Hiroshi Ochiai,Ryo Saito,Shinichi Kusaka,Toshiyuki Kume

CHEMICAL COMMUNICATIONS（2023）

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摘要

We report that a selective fluorescent indicator NBD-NCD for UGGAA repeats resulted in fluorescence quenching upon binding to RNA and recovered the fluorescence by displacing NBD-NCD with UGGAA repeat-targeted small molecules. The fluorescent indicator displacement assay using NBD-NCD can detect the interaction of small molecules with UGGAA repeats.

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关键词

fluorescent indicator displacement assay,small molecules,repeat-targeted

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