Rapid Access to Functionalized gamma-Lactams through Copper-Catalyzed Oxidative Cyclization of Diynes
SYNLETT(2023)
Abstract
An efficient copper-catalyzed oxidative cyclization of diynes is described. A range of functionalized gamma-lactams can be readily constructed by using this protocol. This copper-catalyzed oxidative process proceeds through an alkyne oxidation, carbene/alkyne metathesis, and donor-donor carbene oxidation sequence. The use of readily available substrates, high flexibility, a simple procedure, and mild reaction conditions render the procedure a viable alternative for the preparation of functionalized gamma-lactams.
MoreTranslated text
Key words
copper catalysis, diynes, oxidation, carbene/alkyne metathesis, gamma-lactams
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined