Stereoselective synthesis of alpha-glucosides with glucosyl (Z)-Ynenoates as donors

A SPhosAuNTf2-promoted DMF-modulated glycosylation approach with glycosyl (Z)-ynenoates as donors was developed for highly alpha-selective synthesis of various linkage types of alpha-glucans. The substituent groups were also found to play a significant role in the alpha-selective glucosylation reactions. The glycosylation approach was effectively applied to the stereospecific synthesis of the alpha-1,6-linked triglucoside.