A combination of exercise and calorie restriction improves the development of obesity-related type 2 diabetes mellitus in KKAy mice

Takumi Sugimoto,Ran Uchitomi, Takumi Onishi,Yasutomi Kamei

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY（2023）

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摘要

We observed that exercise and calorie restriction reduced the body weight and blood glucose levels, concurrently improving insulin resistance and glucose tolerance in obese/diabetic model KKAy mice. Analysis of gene expression in the skeletal muscle showed enhanced mRNA levels of GLUT4 (glucose uptake), ATGL (lipolytic enzyme), and slow-twitch myosin heavy chain, which may contribute to the antiobesity and antidiabetic effects.

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关键词

type 2 diabetes mellitus,obesity,exercise,calorie restriction,glucose tolerance

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