Drebrin promotes lung adenocarcinoma cell migration through inducing integrin 1 endocytosis

Lung adenocarcinoma (LUAD) is the most common type of lung cancers, which remains the leading cause of cancer-related death worldwide. Drebrin can promote cell migration and invasion with poor prognosis, but its roes in LUAD tumor progression remains unknown. We showed that the expression of Drebrin was upregulated in clinical LUAD samples. A Kaplan-Meier survival analysis showed that a high expression of Drebrin predicated poor prognosis in LUAD. In vitro, Drebrin promoted anchorage-independent growth and migration of LUAD cells. Drebrin interacted with dynamin through CT domain, and served as an adaptor to promote LUAD cell migration through inducing integrin beta 1 endocytosis. Thus, this study demonstrated the critical role of Drebrin in LUAD and associated mechanism. (C) 2022 Elsevier Inc. All rights reserved.