Dynein-driven self-organization of microtubules: An entropy- and network-based analysis
arxiv(2023)
摘要
Microtubules self-organize to form part of the cellular cytoskeleton. They
give cells their shape and play a crucial role in cell division and
intracellular transport. Strikingly, microtubules driven by motor proteins
reorganize into stable mitotic/meiotic spindles with high spatial and temporal
precision during successive cell division cycles. Although the topic has been
extensively studied, the question remains: What defines such microtubule
networks' spatial order and robustness? Here, we aim to approach this problem
by analyzing a simplified computational model of radial microtubule
self-organization driven by a single type of motor protein – dyneins. We
establish that the spatial order of the steady-state pattern is likely
associated with the dynein-driven microtubule motility. At the same time, the
structure of the microtubule network is likely linked to its connectivity at
the beginning of self-organization. Using the continuous variation of dynein
concentration, we reveal hysteresis in microtubule self-organization, ensuring
the stability of radial filament structures.
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