Encapsulation of natural drug gentiopicroside into zinc based Zeolitic Imidazolate Frameworks (ZIF-8): In-vitro drug release and improved antibacterial activity
Journal of Drug Delivery Science and Technology(2023)
摘要
In the present study, multifunctional natural drug gentiopicroside (GPS) has been encapsulated into zeolitic imidazolate frameworks (ZIF-8) in aqueous solution at room temperature. ZIF-8 MOFs were observed to be suitable and favorable carrier for delivery of GPS. The single step synthesis of GPS@ZIF-8 reflected high loading efficacy of GPS into ZIF-8 of about 84%, while, its loading capacity was revealed to be 10.77%. GPS@ZIF-8 and ZIF-8 were characterized through different techniques. Morphology of GPS@ZIF-8, assessed through SEM and TEM, revealed to be uniform and hexagonal shape which is much alike to pure ZIF-8. Moreover, average particle size of ZIF-8 and GPS loaded into ZIF-8, as observed through DLS, was 125 nm and 149 nm, respectively; increased size of GPS@ZIF-8 depicted a well efficient encapsulation of GPS. The thermal stability showed that the GPS when loaded into ZIF-8 remained thermally constant up to 298 degrees C. The free drug GPS release profile from GPS@ZIF-8 was studied at 37 degrees C in PBS solution with two pH i.e. 5.0 and 7.4. The GPS@ZIF-8 reflected significant faster release of GPS in acidic medium i.e. 81.31% which was higher than the release of GPS in physiological medium i.e. 20.03%. Thus, results of the present study revealed that the ZIF-8 can be used as a potential carrier for controlled delivery of GPS against diseased cells in future. GPS@ZIF-8 in contrast to free GPS showed highest inhibition zone against gram-negative and gram-positive bacteria. Therefore, the composite material can be potentially considered for the therapeutic applications.
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关键词
zeolitic imidazolate frameworks,natural drug gentiopicroside,zinc,in-vitro
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