Seeking clarity on sex differences in cardiovascular complications of Down syndrome.

American journal of physiology. Heart and circulatory physiology(2023)

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Editorial FocusIntegrative Cardiovascular Physiology and PathophysiologySeeking clarity on sex differences in cardiovascular complications of Down syndromeMaggie P. Y. LamMaggie P. Y. LamDivision of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United StatesDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United StatesConsortium for Fibrosis Research and Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United StatesPublished Online:12 May 2023https://doi.org/10.1152/ajpheart.00210.2023This is the final version - click for previous versionMoreSectionsFull TextPDF (236 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat REFERENCES1. Lam CSP, Arnott C, Beale AL, Chandramouli C, Hilfiker-Kleiner D, Kaye DM, Ky B, Santema BT, Sliwa K, Voors AA. Sex differences in heart failure. Eur Heart J 40: 3859–3868c, 2019. doi:10.1093/eurheartj/ehz835. Crossref | PubMed | ISI | Google Scholar2. Bates ML, Vasileva A, Flores LDM, Pryakhina Y, Buckman M, Tomasson MH, DeRuisseau LR. Sex differences in cardiovascular disease and dysregulation in Down syndrome. Am J Physiol Heart Circ Physiol 324: H542–H552, 2023. doi:10.1152/ajpheart.00544.2022. Link | Google Scholar3. InanlooRahatloo K, Liang G, Vo D, Ebert A, Nguyen I, Nguyen PK. Sex-based differences in myocardial gene expression in recently deceased organ donors with no prior cardiovascular disease. PLoS One 12: e0183874, 2017. doi:10.1371/journal.pone.0183874. Crossref | PubMed | ISI | Google Scholar4. Lam MP, Venkatraman V, Xing Y, Lau E, Cao Q, Ng DC, Su AI, Ge J, Van Eyk JE, Ping P. Data-driven approach to determine popular proteins for targeted proteomics translation of six organ systems. J Proteome Res 15: 4126–4134, 2016. doi:10.1021/acs.jproteome.6b00095. 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Circulation 147: 425–441, 2023. doi:10.1161/CIRCULATIONAHA.122.059706. Crossref | PubMed | ISI | Google Scholar Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation CollectionsAJP-Heart CollectionsSex as a Biological VariableThis collection highlights the need in the cardiovascular field to integrate sex and gender in experimental design, data analysis, and reporting of findings.Integrative Cardiovascular Physiology and PathophysiologyThis collection contains research and reviews of cardiovascular function at all levels of organization, ranging from the intact and integrative animal and organ function to the cellular, subcellular, and molecular levels. Related ArticlesSex differences in cardiovascular disease and dysregulation in Down syndrome 23 Mar 2023American Journal of Physiology-Heart and Circulatory Physiology More from this issue > Volume 324Issue 6June 2023Pages H863-H865 Crossmark Copyright & PermissionsCopyright © 2023 the American Physiological Society.https://doi.org/10.1152/ajpheart.00210.2023PubMed37115628History Received 14 April 2023 Accepted 21 April 2023 Published online 12 May 2023 Published in print 1 June 2023 Keywordsagingcardiovascular complicationsDown syndromemedical recordssex differences Metrics
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