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Intravenous Thrombolysis 4.5-9 Hours After Stroke Onset - a Cohort Study from the TRISP Collaboration.

Valerian L Altersberger,Gerli Sibolt,Lukas S Enz, Christian Hametner,Jan F Scheitz,Hilde Henon,Guido Bigliardi,Davide Strambo,Nicolas Martinez-Majander,Lotte J Stolze,Mirjam R Heldner,Ilaria Grisendi,Dejana R Jovanovic,Yannick Bejot,Alessandro Pezzini,Ronen R Leker,Georg Kägi,Susanne Wegener,Carlo W Cereda,Georges Ntaios,Gian Marco De Marchis,Leo H Bonati,Marios Psychogios,Philippe Lyrer,Silja Räty,Marjaana Tiainen,Anke Wouters,François Caparros,Miriam Heyse,Hebun Erdur,Visnja Padjen, Marialuisa Zedde,Marcel Arnold,Paul J Nederkoorn,Patrik Michel, Andrea Zini,Charlotte Cordonnier, Christian H Nolte,Peter A Ringleb,Sami Curtze,Stefan T Engelter,Henrik Gensicke

Annals of neurology（2023）

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Abstract
This study showed no evidence in difference of sICH, poor outcome and mortality in selected stroke patients treated with IVT between >4.5-9 hours after stroke onset compared to those treated within 4.5 hours. Advanced neuroimaging for patient selection was associated with lower mortality. This article is protected by copyright. All rights reserved.
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