Are two riboses better than one? The case of the recognition and activation of adenosine receptors.
ChemMedChem(2023)
摘要
Traditionally, molecular recognition between the orthosteric site of adenosine receptors and their endogenous ligand occurs with a 1:1 stoichiometry. Inspired by previous mechanistic insights derived from Supervised Molecular Dynamics (SuMD) simulations, which suggested an alternative 2:1 binding stoichiometry, we synthesized BRA1, a bis-ribosyl adenosine derivative, tested its ability to bind to and activate the members of the adenosine receptors family, and rationalized its activity through molecular modeling.
更多查看译文
关键词
adenosine receptors * adenosine * bis-ribosyl-adenosine * receptor recognition * receptor activation* bitopic ligand
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要