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Inhibition of TRF2 Leads to Ferroptosis, Autophagic Death, and Apoptosis by Causing Telomere Dysfunction.

Qiuhui Yang,Ziyang Nie,Yukun Zhu, Mingying Hao,Siqi Liu,Xuelu Ding,Feng Wang,Fei Wang,Xin Geng

Oxidative medicine and cellular longevity（2023）

Cited 2|Views19
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Abstract
Our data suggest that TRF2 depletion can inhibit cell growth, proliferation, and migration through the combined action of ferroptosis, autophagic death, and apoptosis in GC cells. The results indicate that TRF2 might be used as a potential target to develop therapeutic strategies for treating GC.
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