Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway.

Stephen J Harwood,Christopher R Smith,J David Lawson,John M Ketcham

International journal of molecular sciences（2023）

Cited 0|Views14

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Abstract

Within the MAPK/RAS pathway, there exists a plethora of protein-protein interactions (PPIs). For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes to provide much needed therapies for patients with -mutant driven cancers. In this review, we focus on recent strategies to inhibit RAS-signaling via disrupting PPIs associated with SOS1, RAF, PDEδ, Grb2, and RAS.

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Key words

KRAS,MAPK,RAS,X-ray crystallography,protein–protein interactions

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