Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin.

Vikram Bhatia,Saeid Maghsoudi,Martha Hinton,Anjali Y Bhagirath,Nisha Singh,Appalaraju Jaggupilli,Prashen Chelikani,Shyamala Dakshinamurti

Biology（2023）

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摘要

FSK-interacting amino acids are not involved in the hypoxic inhibition mechanism. This study provides direction to design FSK derivatives for selective activation of hypoxic AC6.

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关键词

adenylyl cyclase,cyclic AMP,forskolin,homology modeling,site-directed mutagenesis

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