The impact of PIK3CA mutations and PTEN expression on the effect of neoadjuvant therapy for postmenopausal luminal breast cancer patients.

Shouko Hayama,Rikiya Nakamura,Takayuki Ishige,Takafumi Sangai,Masahiro Sakakibara,Hiroshi Fujimoto,Emi Ishigami,Takahito Masuda,Ayako Nakagawa,Ryotaro Teranaka,Satoshi Ota,Sakae Itoga,Naohito Yamamoto,Takeshi Nagashima,Masayuki Otsuka

BMC cancer（2023）

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摘要

PIK3CA mutations are associated with resistance to NAC but do not affect the response to NAE. Low PTEN expression does not affect response to either NAC or NAE but correlates with shorter RFS in patients who received NAC. These biomarkers will be further evaluated for clinical use to treat postmenopausal luminal breast cancer patients.

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关键词

Breast neoplasms,Neoadjuvant therapy,PTEN Phosphohydrolase,Phosphatidylinositol 3-Kinases/genetics,Prognosis

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