Bidirectional associations and a causal mediation analysis between depressive symptoms and chronic digestive diseases: A longitudinal investigation

Jiali Zheng,Jingmeng Li,Tianduo Pei,Tianren Zhu,Xiaoguang Li,Hui Wang

Journal of Affective Disorders（2023）

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Abstract

•Research advances in brain-gut axis suggested a bidirectional association between depression and chronic digestive diseases.•Prospective bidirectional associations between depression and chronic digestive diseases were examined in Chinese adults•Depression and chronic digestive diseases were mutually independent risk factors•Shorter sleeping duration at night mediated 8.8% of association between depression and incident digestive diseases.

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Key words

ANOVA,BMI,CDD,CES-D-10,CHARLS,CI,CNS,ENS,GERD,GBD,GI,HDL,HR,hsCRP,IBD,IBS,LDL,IL-1β,MET,MGB,MTE,NAFLD,NDE,NIE,WBC

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