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Inhibition of MRTF activation as a clinically achievable anti-fibrotic mechanism for pirfenidone.

Hsiao-Yen Ma,Jason A Vander Heiden,Salil Uttarwar,Ying Xi,Elsa-Noah N'Diaye,Ryan LaCanna,Patrick Caplazi,Sarah Gierke,John Moffat,Paul J Wolters,Ning Ding

The European respiratory journal（2023）

Cited 5|Views27
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Abstract
Our results suggest MRTF signalling as a direct target for PFD and implicate that some of the anti-fibrotic effects of PFD may be due to MRTF inhibition in lung fibroblasts.
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mrtf activation,anti-fibrotic
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