Class a capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.

Dieudonné Buh Kum,Hannah Vanrusselt,Abel Acosta Sanchez,Valerio Taverniti,Eloi R Verrier,Thomas F Baumert, Cheng Liu,Jerome Deval,Nikky Corthout,Sebastian Munck,Leonid Beigelman,Lawrence M Blatt,Julian A Symons,Pierre Raboisson,Andreas Jekle,Sandrine Vendeville,Yannick Debing

Hepatology (Baltimore, Md.)（2023）

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摘要

Our study unravels a previously unknown mechanism of action for CAM-As such as RG7907 in which HBc aggregation induces cell death, resulting in hepatocyte proliferation and loss of covalently closed circular DNA (cccDNA) or its equivalent, possibly assisted by an induced innate immune response. This represents a promising approach to attain a functional cure for CHB.

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关键词

hepatocytes,capsid assembly modulator rg7907,hbv-infected,core-dependent

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