Predictive Value of HDL-C/TC Ratio for Recurrent Revascularization Events in Elderly Diabetes Patients with Coronary Heart Disease

Objective To explore the clinical predictive value of HDL-C/TC ratio based on DCA for recurrent revascularization events in elderly diabetes patients after PCI.Methods A total of 512 elderly diabetes patients with a history of PCI admitted in our department from January 2012 to November 2021 were enrolled in this study.According to occurrence of revascularization events, they were divided into control group（n=391） and case group（n=121）.The risk factors related to revascularization events were analyzed by Cox regression model.The effect of HDL-C/TC on the events was detected by Kaplan-Meier curve, and the clinical benefit of risk model was evaluated by DCA.Results Complex vascular disease, higher LDL-C,TC and TG levels, while lower HDL-C/LDL-C and HDL-C/TC ratios were observed in the case group than the control group（P＜0.05,P＜0.01）.The HDL-C/TC ratio and complex vascular disease were independent risk factors for recurrent revascularization events after PCI in elderly diabetes patients（95%CI:0.267-0.565,P=0.000;95%CI:1.149-2.409,P=0.007）.At the 24th, 36th, 48th and 60th months of observation, the recurrence rate of revascularization events in the patients with HDL-C/TC ＞0.26 was significantly lower than that in those with the ratio ≤0.26（P＜0.01）.DCA suggested that the area under the clinical DCA curve was significantly higher when HDL-C/TC was included than when HDL-C/TC was not.Conclusion Low HDL-C/TC is a risk factor for recurrent revascularization events in elderly diabetes patients after PCI.