Intermolecular proton transfer from flavonol to human serum albumin triggers a red-shifted ratiometric fluorescence response

Zhongyong Xu,Mingyuan Zhang,Zihao Chen,Yutian Zhao,Lei Wang,Xiaoqiang Chen,Bin Liu,Xiaojun Peng

Chemical communications (Cambridge, England)（2023）

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摘要

Intermolecular proton transfer from a flavonol-based probe to the arginine (Arg222) in drug site 1 of human serum albumin triggers an unusual red-shifted ratiometric fluorescence response, which can be applied in the point-to-care diagnosis of hypoalbuminemia.

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关键词

human serum albumin,serum albumin,flavonol,intermolecular proton transfer,fluorescence,red-shifted

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