Electroconductive and mechano-competent PUCL@CNT nanohybrid scaffolds guiding neuronal specification of neural stem/progenitor cells
Chemical Engineering Journal（2023）
Abstract
•An electroconductive platform (PUCL@CNT) was developed for neuronal regeneration.•It provided electroconductivity, nanotopography, and mechano-competent properties.•The neuronal specification was guided by Ca2+ dependent FAK-AKT-β-catenin pathway.•Endogenous NSPCs and neurons were more observed in neural tissue near PUCL@CNT.•PUCL@CNT is revealed to have remarkable potential for neural tissue regeneration.
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Key words
Carbon nanotubes, Polyurethane-polycaprolactone, Neuronal differentiation, Focal adhesion, Intracellular calcium, Neural tissue regeneration
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