Visual Analysis of Clinical Studies of Xuebijing Injection Based on Bibliometrics^*

OBJECTIVE To analyze the current situation and development trend of Xuebijing injection research based on relevant literature of clinical research on Xuebijing injection, and to provide a reference for subsequent studies. METHODS The literature related to the clinical study of Xuebijing injection was searched from CNKI, Wanfang V2.0, VIP Chinese Journal Service platform, and SinoMed (China Biomedical Literature Service System) for the period from the establishment of the database to March 2022. CiteSpace 5.8.R3 was used to analyze the research hotspots, perform cluster analysis, build knowledge graphs, organize the statistical and visual analysis of the diseases, syndrome types, and drug combinations involved in the literature, and explore the cross-sectional association among the studies by using bibliometric methods. RESULTS The final included literature was 2253 articles. In recent years, the amount of literature published in this field tends to be stable, and a relatively stable core team has been formed, but there is less cooperation among research teams, sepsis and pneumonia are the current research hotspots. The main clinical diseases treated by Xuebijing injection involve 19 categories, with a wide therapeutic scope, and the main syndrome type of treatment syndrome is blood stasis syndrome, which is mostly combined with related drugs and therapies in disease treatment. The efficacy is significantly improved after intervention for severe COVID-19, but the quality of relevant literature is generally low. CONCLUSION Xuebijing injection has high research interest, diversified and detailed research direction, and has extensive clinical application. It has an outstanding therapeutic effect in the treatment of critical illness type of disease, and the combination with related drugs and therapies is universal in the treatment of the disease. It has a significant curative effect in the treatment of severe COVID-19, and has a promising clinical application.