The correlation between neuropathology levels and cognitive performance in centenarians.

Meng Zhang,Andrea B Ganz,Susan Rohde, Linda Lorenz,Annemieke J M Rozemuller, Kimberley van Vliet, Marieke Graat,Sietske A M Sikkes,Marcel J T Reinders,Philip Scheltens,Marc Hulsman,Jeroen J M Hoozemans,Henne Holstege

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要

Only Braak-NFT stage and limbic-predominant age-related TDP-43 encephalopathy (LATE) pathology associated significantly with performance across multiple cognitive domains. Of all cognitive tests, the clock-drawing test was particularly sensitive to levels of multiple neuropathologies.

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cognitive performance,neuropathology levels,centenarians

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