The microbiome in adolescents with irritable bowel syndrome and changes with percutaneous electrical nerve field stimulation.

Daniel F Castillo,Lee A Denson,David B Haslam,Kevin A Hommel,Nicholas J Ollberding,Rashmi Sahay,Neha R Santucci

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society（2023）

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摘要

Firmicutes, including Clostridiaceae spp., and LCFA synthesis pathways were increased in IBS patients suggesting pain-potentiating effects. PENFS led to marked improvements in abdominal pain, functioning, and catastrophizing, while Clostridial species and LCFA microbial pathways decreased with treatment, suggesting these as potential targets for IBS centrally mediated treatments.

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fatty acids,gastrointestinal microbiome,irritable bowel syndrome,metabolic pathways,pediatrics,percutaneous electrical nerve field stimulation

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