Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer.

Liwei Lang, Fanghui Chen,Yamin Li,Chloe Shay,Fan Yang,Hancai Dan,Zhuo G Chen,Nabil F Saba,Yong Teng

Cancer research communications（2023）

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摘要

This work provides novel insights into c-Met-PLXDC2 signaling in radioresistance-associated aggressiveness and suggests a new mechanism-informed therapeutic strategy to overcome failure of radiotherapy in patients with HNSCC.

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关键词

neck cancer,signaling,c-met-plxdc,radioresistance-associated

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