Whole Genome DNA Methylation and Mutational Profiles Identify Novel Changes in Proliferative Verrucous Leukoplakia.

Eyituoyo M Okoturo,Daniel Green,Kim Clarke,Triantafyllos Liloglou,Mark T Boyd,Richard J Shaw,Janet M Risk

Oral surgery, oral medicine, oral pathology and oral radiology（2023）

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摘要

Specific differences in mutation and methylation profiles between PVL-derived OSCC and OSCC of non-PVL origin suggest differences in their transformation pathways. Further studies of early PVL lesions may identify markers of transformation that are also applicable to more common oral premalignant disorders such as oral epithelial dysplasia.

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whole genome dna methylation,mutational profiles

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