Tissue optics for margin assessment in breast conserving surgery: Systematic review & meta-analysis

Introduction: Up to 19% of patients require re-excision surgery due to positive margins in breast conserving surgery (BCS). Intraoperative margin assessment tools (IMA) that incorporate tissue optical measurements could help reduce re-excision rates. This review focuses on methods in which diffusely reflected light has been interrogated for breast cancer detection in the intraoperative setting.