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Outcomes of Second-Line Therapies in Patients with Metastatic de Novo and Treatment-Emergent Neuroendocrine Prostate Cancer: A Multi-Institutional Study

Corbin J. Eule,Junxiao Hu, Sulaiman Al-Saad,Katharine Collier,Patrick Boland,Akeem R. Lewis,Rana R. McKay,Vivek Narayan,Dominick Bosse,Amir Mortazavi,Tracy L. Rose,Brian A. Costello,Alan H. Bryce,Elaine T. Lam

Clinical Genitourinary Cancer（2023）

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Abstract
In this retrospective study, patients with de novo NEPC or T-NEPC who received second-line therapy were treated with wide variety of treatment regimens, reflecting the lack of consensus in this setting. Most patients received chemotherapy-based treatments. Overall prognosis was poor and ORR was low in the second line regardless of treatment choice.
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Small cell,Chemotherapy
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