Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL

Anne Largeot,Vanessa Klapp,Elodie Viry,Susanne Gonder,Iria Fernandez Botana,Arnaud Blomme,Mohaned Benzarti,Sandrine Pierson,Chloé Duculty,Petra Marttila,Marina Wierz,Ernesto Gargiulo,Giulia Pagano,Ning An,Najla El Hachem,Daniel Perez Hernandez,Supriya Chakraborty, Loïc Ysebaert,Jean-Hugues François, Susan Cortez Clemente

Blood（2023）

引用 2|浏览59

暂无评分

摘要

•Inhibition of translation initiation prevents CLL growth in vitro and in vivo, through targeting the MYC oncogene.•PHBs directly interact with the translation initiation machinery, filling a gap in the understanding of the crucial roles of these proteins.

查看译文

关键词

myc translation,therapeutic strategy,phb-eif

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要