Understanding the relationship between loneliness, substance use traits and psychiatric disorders: a genetically informed approach
Psychiatry Research(2023)
摘要
•Genomic Structural Equation Modelling was used to implement factor analysis on 11 psychiatric traits.•The 11 psychiatric traits clustered into three latent genetic factors encompassing neurodevelopmental/mood conditions, substance use traits and disorders with psychotic features.•Loneliness was uniquely genetically associated with the latent factor representing neurodevelopmental/mood conditions.•Mendelian randomization provided evidence suggesting a bidirectional causal effect between loneliness and neurodevelopmental/mood conditions.
更多查看译文
关键词
Genetics,Mendelian randomization,Genomic structural equation modelling,Depression,Neurodevelopmental disorders, Mood disorders
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要